[a][3][4][5] Ironmouse originally planned to pursue a career as a coloratura soprano opera singer, but was diagnosed with common variable immunodeficiency (CVID), an immune disorder that has left her largely bedridden and isolated.

It has also led to a lung infection called mycobacterium avium complex as she revealed to Projekt Melody in 2021.

[7][12] Amid a growth trend for streamers in general, and especially VTubers,[13][14] Ironmouse's audience on Twitch began to see increases over 2020 and 2021.

[7] In November 2020, Ironmouse was announced as one of the charter members of VShojo, a new U.S.-based agency of English-language VTubers, joining other streamers and personalities such as Nyanners and Projekt Melody.

[15][16] Ironmouse is known for her frequent collaborations with Welsh YouTuber CDawgVA; he had learned of VTubers via Gigguk—one of his colleagues on the Trash Taste podcast.

After watching an Ironmouse stream on Twitch out of curiosity and finding her to be "really funny", CDawgVA brought her up during a Trash Taste episode with Hololive English member Mori Calliope as a guest.

[17][18] In February 2022, Ironmouse held a subathon event, a nonstop stream in which a countdown clock was extended whenever viewers purchased paid subscriptions or otherwise made donations to the channel.

[31] On September 10, 2024, YouTube suspended Ironmouse's VOD channel, supposedly due to copyright strikes.

[34] That same month, Ironmouse overtook Kai Cenat as the most-subscribed channel on Twitch, setting a new all-time record for the service on September 30.

This caused many creators like CDawgVA to follow in her footsteps and raise more money for the charity, In an interview with the Immune Deficiency Foundation, CDawgVA stated "I find that often it’s the people that we really care about who… force us to learn about stuff we’ve been ignorant about or that we’ve allowed to be ignorant about because we haven’t had to deal or be exposed to any of the ideas.

"[18]Her efforts for raising awareness were also well recognized by the Immune Deficiency Foundation (IDF), which earned her the "plasma hero award" on 2024 PI Conference.