Irv is credited with having helped discover or sign rappers Jay-Z, DMX, and Ja Rule, as well as singers Ashanti and Lloyd.

He executively produced the debut albums for DMX's It's Dark and Hell Is Hot, Ja Rule's Venni Vetti Vecci, Ashanti's self titled, and Lloyd's Southside.

), The Inc. (Irv Gotti Presents: The Inc.), Ashanti (Chapter II, Concrete Rose), and Lloyd (Street Love)—as well as singles for other artists such as Jennifer Lopez (I'm Real (Murder Remix), Ain't It Funny (Murder Remix)), Fat Joe (What's Luv), Eve (Gangsta Lovin'), and Kanye West (Violent Crimes), among others.

During his time at TVT, he signed Mic Geronimo and Queens-based rap group Cash Money Click, of which rapper Ja Rule was a member.

The same year Irv received a Guinness World Record for having produced a Billboard Hot 100 single that had the number one position for nineteen weeks consecutively.

[11][5] Under The Inc. banner, Gotti moved the label to Universal Motown and signed Vanessa Carlton,[20] co-producing her third album, Heroes and Thieves, which was released October 9, 2007, with Channel 7, Rick Rubin, and Stephan Jenkins.

[22] 2003 money laundering case On January 3, 2003, federal agents and New York Police Department investigators raided the headquarters of Murder Inc. Records, located at One Worldwide Plaza in Midtown Manhattan.

The raid was a part of a year-long investigation into the connection between the Lorenzo brothers and American drug lord Kenneth "Supreme" McGriff.

Investigators believed that the Lorenzos used drug money supplied by McGriff to launch Murder Inc. as a way to launder the illegal funds.

Investigators also believed the brothers helped McGriff launder drug money through the making of the 2003 film Crime Partners.

[25] Lorenzo had suffered a minor stroke in early 2024 as a result of his diabetes, which caused him to change his dietary habits.