Is-sur-Tille (French pronunciation: [is syʁ tij]) is a commune in the Côte-d'Or department of Bourgogne-Franche-Comté France.

Is-sur-Tille is located about twenty kilometers north of Dijon, on the river Ignon, close to its confluence with the Tille.

To the west is a heavily forested limestone plateau with an elevation of over 400 meters.

To the east is a humid clay plain sloping gently to the southeast of the Saône.

This Côte-d'Or geographical article is a stub.