The Clark Sisters recorded the song and album live at Bailey Cathedral Church of God in Christ in Detroit, Michigan.
The song proved to be the first big hit for the quintet, propelling them to national exposure.
[1] Each sister sings a line of the song, vocally declaring that their dedication to Christ is not a useless effort.
[2] On August 31, 2018, the Clark Sisters performed the song live at Aretha Franklin's funeral in Detroit.
[3] In 1993, American group Xscape covered "Is My Living in Vain" for their debut album Hummin' Comin' at 'Cha.