Isaías Medina Angarita (6 July 1897 – 15 September 1953) was a Venezuelan military and political leader, the president of Venezuela from 1941 until 1945, during World War II.

As a result of the indirect 1941 Venezuelan presidential election, he was appointed president by lawmakers of the Congress of Venezuela.

First, in 1943 to the Bolivarian countries, Colombia, Ecuador, Peru, Bolivia and Panama, and in January 1944, the United States invited by Franklin Delano Roosevelt.

Some in the Army considered his presidential regime too liberal while other political enemies accused him of being too conservative, and both sides were involved in a coup to remove him from power on 18 October 1945.

Isaías Medina Angarita was married to Irma Felizola,[citation needed] who served as First Lady of Venezuela from 1941 to 1945.