Isa-Beg Ishaković was appointed as sanjak-bey (provincial governor) of the Sanjak of Skopje in the spring of 1439, in place of his father, Ishak-Beg, who was sent to lead military actions in Serbia.
Ishaković built many important buildings part of the Old Bazaar in Skopje, like the Čifte Hammam, Kapan Han, Ishak Bey Mosque (dedicated to his father Ishak-Beg, also known as Isaklija or Aladža), the madrasa (Islamic school) and library (within Isak-Beg's Mosque, one of the first Islamic libraries in Europe),[3] and many other buildings that belonged to his endowment (waqf, Bosnian: vakuf).
Po drugima, Isak Hranić/Hranušić zarobljen je tijekom jednog upada akindžija na posjed velikaške obitelji Pavlović, inače gospodara velikog dijela Istočne Bosne, uključujući i srednjovjekovnu župu Vrhbosnu.
Potpuno drukčiji pristup na porijeklo Ishakovića imaju istraživanja historičarke umjetnosti Lidije Bogojević Kumbaradži iz Skoplja.
Zanimljivosti idu do mjere u kojoj se skopski begovi Kumbaradžije smatraju izravnim potomcima Isa-bega Ishakovića, o čemu posjeduju i autentičnu dokumentaciju.