Isaac Cox Cobblestone Farmstead, also known as the Letson Farm, is a historic home and farm complex located in the town of Wheatland near Scottsville in Monroe County, New York.

The complex includes a Federal style cobblestone farmhouse built about 1838.

It is constructed of small to medium-sized field cobbles and is one of seven surviving cobblestone buildings in the town of Wheatland.

Also on the expansive property are a pair of Wells truss barns, 19th century combination corn crib / pig sty, and small 19th century smokehouse.

This article about a historic property or district in Monroe County, New York, listed on the National Register of Historic Places, is a stub.