Sir Isaac Holden, 1st Baronet (7 May 1807 – 13 August 1897) was an inventor and manufacturer, who is known both for his work in developing the Square Motion wool-combing machine and as a Radical Liberal Member of Parliament.

He was apprenticed from the age of ten for a short period as a draw boy for two hand weavers, but attended the grammar school run by the 'Old Radical' John Fraser.

The following year Holden returned to Scotland to set up a night school in Glasgow, but after a brief period of teaching he moved in 1830 to become a bookkeeper at Townsends' worsted factory in Cullingworth near Bingley.

Transferring to the technical side and becoming a manager, he spent his time at seeking to improve the process of combing wool.

Holden left Townsends in 1846 to set up a factory making Paisley shawl middles at Pit Lane in Bradford.

In 1865 Holden was elected to serve as a Liberal Member of Parliament for Knaresborough from 1865 to 1868, and later for the Northern West Riding of Yorkshire from 1882 to 1885 and for Keighley from 1885 to 1895.