[11] He scored a career-high 12 points in his last college game, Kentucky's 73–75 loss to the North Carolina Tar Heels in the South Region finals where he was also named in the NCAA All-Regional tournament team.

[15] Humphries returned to Australia and signed with his hometown team the Sydney Kings on 27 July 2017 for the 2017–18 NBL season.

[16] With the Kings, Humphries averaged 6.9 points, 3.6 rebounds and 1.0 blocks while shooting 58 percent in 16 minutes per game, making six starts in 26 appearances.

[19][20] On 8 October 2018, Humphries signed a training camp deal with the Atlanta Hawks,[21] but was waived the next day.

[24][25] Humphries joined the Los Angeles Clippers for the 2019 NBA Summer League in Las Vegas.

[34] He played just six matches, averaging 7.7 points in 17.7 minutes per game, before a knee injury ruled him out for the season in February 2022.

In 2014, he helped Australia win the silver medal at the FIBA Under-17 World Championship, averaging 18.9 points, 11.6 rebounds and 3.3 blocks per game during the tournament.

[44] Humphries made his senior debut for the Australian national team in a 2019 FIBA World Cup qualifying match against Kazakhstan, where he recorded 17 points and 7 rebounds in a dominant performance.

[4] He restarted his music career after some years immersed in basketball, during which time he started learning new instruments that he could play anywhere.

[48][49] The announcement saw Humphries become the only active openly gay male professional basketball player in a top-tier league anywhere in the world.

[48][52] He posted a video online, which was shared widely, including by Lauren Jackson, Dylan Alcott, and Andrew Gaze.

By February 2023 it had garnered around 10 million views, with mostly positive responses, including messages from Tones and I and Dannii Minogue.