Isaac M. Powers House is a historic home located at Wallace, Duplin County, North Carolina.

It was built about 1878, and is a one-story, single pile, three bay, frame dwelling with Greek Revival style design elements.

It was the home of Reverend Isaac Powers (1850-1936), one of the first African-American landowners in Duplin County.

[2] It was listed on the National Register of Historic Places in 1999.

This article about a property in Duplin County, North Carolina on the National Register of Historic Places is a stub.