Isaac C. Naylor (1 Jul 1824 – 16 Apr 1885) was an attorney, postal clerk, merchant and bookkeeper.

[1][2] He operated the Select Academy in Galveston, Texas[3] until 1856 and studied law with Sherwood & Goddard there.

While Naylor was mayor, he also served on the defense team of City Marshal Andrew M. Moore, who was charged with the murder of Alexander Cockrell.

[7] During the Civil War he left his family in Galveston and moved to California and later New York because his sympathies were with the Union.

[8] Isaac Naylor returned to Galveston worked for his father-in-law as a clerk, bookkeeper, and merchant.