The Isaac Region is a local government area located in Central Queensland, Queensland, Australia created in March 2008 as a result of the report of the Local Government Reform Commission released in July 2007.

Its traditional language region was within the local government area of Isaac Region, from the headwaters of the Belyando River south to Avoca, north to Laglan, west to the Great Dividing Range, and east and south to Drummond Range.

The Isaac Regional Council covers an area of 58,708 square kilometres (22,667 sq mi),[2] had a population in 2018 of 20,934[2] and an operating budget of A$46.0m.

The region takes its name from the Isaac River, which in turn takes its name from Queensland pioneer Frederick Isaac who accompanied the explorer Ludwig Leichhardt on his first expedition.

[6] Isaac Regional Council operates public libraries in Carmila, Clermont, Dysart, Glenden, Middlemount, Moranbah, Nebo, and St Lawrence.