Roosevelt was born on September 29, 1790, in New York City,[1] he was the oldest surviving son of businessman and politician James Roosevelt (1760–1847) and Maria Eliza Walton (1769–1810),[2] the daughter of Admiral Gerard Walton (d. 1821) and a descendant of Wilhelmus Beekman, who was the treasurer of the Dutch West India Company, Mayor of New York City,[3][4] Governor of Delaware from 1653 to 1664, and Governor of Pennsylvania from 1658 to 1663.

[1] Despite his extensive training, Roosevelt never practiced medicine,[7] reportedly due to his inability to "bear the sight of human suffering.

[1] In 1832, near his father's home, Roosevelt built a house at the center of his estate called Rosedale.

Today it is known as the Isaac Roosevelt House and still stands on Riverview Circle in Hyde Park.

The home was listed on the National Register of Historic Places in 1993, along with a cottage and boathouse on the Hudson River nearby.