Isaac Seneca Jr. (October 7, 1874 – 1945) was an All-American football player for the Carlisle Indian Industrial School.

Then he squirmed and shook off the Yale men, dodged a man or two, and, making a splendid run down the field, made what was thought to be a touchdown.

The New York Times wrote the next day that the referee had made the wrong call and that Carlisle had been robbed of a touchdown, but the game went into the record books as a 12–6 win for Yale.

[1][4][5] In 1899, Glenn "Pop" Warner was hired as the head football coach and athletic director at Carlisle.

Carlisle defeated Columbia 42-0 in a game played in Manhattan on Thanksgiving Day 1899 with 10,000 fans in attendance.

[9] A press account of the game said: "The Indians were in prime physical condition and bore through the Columbia line and skirted the ends at will.

At the end of the 1899 season, Seneca was elected as captain of the 1900 team (though he would opt to play professional football rather than return in 1900).

[10][11] After the regular season, the Carlisle team accepted an invitation to play the University of California, San Francisco on Christmas Day.

[19] At the time of the 1930 United States Census, Seneca was listed as a blacksmith working in Ponca City, Oklahoma.