His father and principle teacher was Rav Judah ben Ezekiel, who was probably quite old when Isaac was born.
[3] His father regarded him highly, and would repeat teachings in his son's name, which was considered unusual, since usually the student would quote the teacher and not the reverse.
[5] Isaac did not marry until a late age, because his father Judah did not know how to find a family with sufficiently good lineage, until Ulla visited and taught Judah a method for estimating lineage.
[10] Along with his brother, Huna bar Judah [he],[11] he debated halacha with Abaye and Rava.
[12] His granddaughter Homa, the daughter of his son Issi, was termed Isha katlanit ("lethal/deadly woman"), since she married three men, all of whom died: Rehaba of Pumbeditha [he], Rab Isaac, the son of Rabbah bar bar Hana, and Abaye.