She is best known for her roles in Home and Away (2003–06), Transformers: Revenge of the Fallen (2009), Daybreakers (2009), The Waiting City (2009), The Pacific (2010), Immortals (2011), A Heartbeat Away (2011), Red Dawn (2012), The Loft (2014), The Water Diviner (2014), Knight of Cups (2015), and That's Not Me (2017).

In 2018, she appeared in In Like Flynn which was a success in Australia, New Zealand, and Britain, and the same year played Brooke in Chasing Comets.

[2] Later in 2009, Lucas won Best Breakout Performance Female at SPIKE TV's 2009 Scream Awards for her role in Transformers: Revenge of the Fallen.

[4] Isabel Lucas was born in Melbourne, Australia, on 29 January 1985,[1][5] and is the daughter of Andrew, a biodynamic farmer and retired pilot, and Beatrice, a special needs teacher.

[8] Lucas was involved in drama during her school years and attended courses at the Victorian College of Arts and Queensland University of Technology.

[1] In 2007, she focused on saving dolphins in Japan,[11] and in October of that year appeared on the Australian Today Show to discuss this topic.

[21] In November 2012, Lucas was featured as the main character in the music video for "Give Me Love" by British singer-songwriter Ed Sheeran.

[31] The same year, she played Kali Stewart in Shooting in Vain, a drama thriller starring Sebastian Gregory, Diana Hopper, and Colleen Kelly.

[32] Lucas appeared in the Australian drama-thriller Shooting in Vain, directed by Jared Januscka, which was released on worldwide in 2018.

[33] In 2022, Lucas starred alongside Luke Hemsworth and Rasmus King in a drama-film, Bosch & Rockit (Ocean Boy).

[44] In an article released following her departure from the U.S., she explained that she moved back to Australia to be around her family more, and for the advantages of working on films in her home country.

[48] She also supported anti-5G theories regarding its rollout in Australia, and was a guest speaker at an anti-5G rally in October 2020 in Byron Bay, stating that 5G could be "potentially ushering a regime of total surveillance".

[52] The group paddled out on surfboards to the dolphins in an attempt to stop the hunt, but they were forced to turn around after being intercepted by one of the fishing boats.

They drove straight to Kansai International Airport and left the country to avoid being arrested for trespassing by the Japanese police.