Isabel Randolph (born Isabelle Elfreda Mair; December 4, 1889 – January 11, 1973) was an American character actress in radio and film from the 1940s through the 1960s and in television from the early 1950s to the middle 1960s.

[3] Randolph acted in regional theater all over the American Midwest, from the pre-World War I era up to the start of her radio career in the mid-1930s.

She re-created her character of Mrs. Uppington in RKO's Look Who's Laughing in 1941 and Here We Go Again in 1942, both spin-offs of the Fibber McGee and Molly radio series.

[17] Her first role on television was a protagonist on the 1951 version of Dick Tracy[citation needed] She played the recurring character of neighbor Mrs. Boone in Meet Millie,[17]: 678  one of the first of the sitcom hits for CBS in 1954.

[18] Later that year she concluded her television career when she played the role of Madam Rosa Bruening in the Perry Mason episode "The Case of the Misguided Model.