When Marina's dead body was discovered, Steve's wife, Kayla Brady was convicted in her murder.
In the summer of 1990, Isabella became a key figure in the infamous Cruise of Deception storyline when Ernesto Toscano, also seeking his late wife Loretta's diary, invited Salem's most prominent members aboard his yacht.
Returning to Salem, Isabella began a private investigation agency with her new-found brother, Bo Brady, and her relationship with Roman deepened.
The couple become engaged and made plans to move in together when Roman's presumed-dead wife, Marlena, returned to Salem.
Devastated, the false Roman reverted to using his old name, John Black, and began a desperate search into his real identity.
The Black family's happiness was short-lived when Dr. Carly Manning informed Isabella her back pain was the result of advanced pancreatic cancer.
In 1993, Marlena and Roman Brady named their newborn daughter Isabella, nicknamed Belle for short.
Isabella's ghost made several guest appearances: in 1995, as part of Satan's plot, and in 2000, while attempting to save Eric Brady.
Later that year, Isabella appeared to John as her former husband prayed for guidance, unsure as how he could best help their angry, now college-age son, Brady.
On Mother's Day in 2019, her son Brady and Kristen DiMera welcomed their daughter Rachel Isabella DiMera Black, who was named after her and Kristen's mother: Rachel Blake, who was switched at birth by Xander Kiriakis, under orders by her great- grandfather Victor to spare his wife Maggie Horton the truth that she's responsible for the deaths of Adrienne Johnson and her granddaughter: the real Mackenzie Horton.
Then, Brady meets Sarah at the Salem Pub after she learns that Kristen is on the run with Rachel and they have decided to plotted to get revenge on Victor and Xander for that they did to them and their children.