Isabelle De Leon was featured in the title role of the GMA drama series Munting Anghel in 2000.
She also appeared in movies such as Magnifico, Bahay ni Lola, Super-B, Sanib, Padre de Pamilya, Litsonero and Soliloquy.
[4][5] De Leon starred recently in a Wattpad entitled Diary ng Hindi Malandi, Slight Lang by Owwsic where she played the lead character Pilar Payoson a.k.a.
She also starred in another Wattpad series entitled Mistakenly Meant for You as the lead character Irina Sobel Samonte a.k.a.
In 2020, she went freelance and returned to ABS-CBN and is currently portraying the role of Marielle Lascano in the longest-running teleserye, Ang Probinsyano.