He worked in the synagogue in Smíchov and for almost his entire professional career as a regional rabbi of the Jewish community in Jungbunzlau (now Mladá Boleslav), then one of the most important in Bohemia.

[1] He first studied at the local grammar school, and between 1834 and 1836 completed a three-year degree course at Charles-Ferdinand University in Prague, graduating in 1841 as Doctor of Philosophy.

Around this time he also received semicha (rabbinic ordination) from the beth din in Prague, which was led by Rabbi Samuel Lobe Kauder.

[2] His book שעשועים בחדרי המשנה מענה חדות ששה סדרי משנה (Šauším behadrej hamišná meanná hidot šišá sidrej mišná) was published in Prague in 1865.

[5][6] Guido's daughter Jenny Weleminsky was an Esperantist and translator, whose work was published in the Budapest Esperanto-language magazine, Literatura Mondo.