The town is the headquarters of Isakhel Tehsil, an administrative subdivision of the district.

[1][2] Isakhel is an important town located in the west of Mianwali District.

Isakhel became part of the newly formed Mianwali District of the Punjab.

[3][4] The town of Isakhel is an old settlement with historic importance dated back to 1100 AD.

During its tribal years, the town was under the chieftainship of various powerful rulers, mostly from the Malik, Awan, or Niazi tribes.