Isaklinsky District (Russian: Исакли́нский райо́н) is an administrative[1] and municipal[5] district (raion), one of the twenty-seven in Samara Oblast, Russia.

It is located in the northeast of the oblast.

The area of the district is 1,578 square kilometers (609 sq mi).

[3] Its administrative center is the rural locality (a selo) of Isakly.

[9] The population of Isakly accounts for 32.4% of the district's total population.