Isaqueena, also known as the Gassaway Mansion, is a historic house in Greenville, South Carolina, and the largest private residence in the Upstate.

[3] As the National Register nomination notes, the three-story house is "an unusual example of eclecticism", blending neo-Gothic and neoclassical elements that include six Doric columns, a Palladian window, a castellated tower, two rooftop patios, and a massive porte-cochère.

[4] Stone for the random bond masonry was in part taken from a mid-nineteenth-century grist mill on the Reedy River owned by Greenville founder Vardry McBee.

The following year his widow abandoned Isaqueena for a smaller home (which she also designed) closer to downtown Greenville.

After the art museum moved to a purpose-built gallery on Greenville's Heritage Green in 1974, the mansion sat vacant until purchased in 1977 for use as a church and school.