Isatou Njie-Saidy (also spelt Aisatu N'Jie-Saidy; born 5 March 1952) is a Gambian politician.

From September to November 1981, she studied at the University of the Philippines, where she obtained a certificate in small-scale industrial information management.

In September 1988, she completed a Masters of Science in Social and Economic Development at the University of Swansea.

Two years after the 1994 Gambian coup d'état in which Yahya Jammeh seized power, in July 1996 Njie-Saidy was appointed as Minister of Health, Social Welfare and Women's Affairs.

On March 20th, 1997 a few months after the 1996 presidential election which was won President Jammeh, Njie-Saidy was appointed as Vice-President of the Gambia and Secretary of State for Health, Social Welfare and Women's Affairs.