Isca sullo Ionio (Calabrian: Jìsca; Greek: Iskia) is a comune and town in the province of Catanzaro in the Calabria region of Italy.

Sometime, probably during the 9th century AD, the inhabitants moved to higher ground, where present day Isca is today, perched between two mountains.

In the immediate days following the earthquake of 1947, talks began and planning of a new community or extension to Isca, that should be built on safer flat ground, near the beach.

In the years to follow, Isca Marina would become a vacation destination for Italian and foreign travelers, on summer holiday.

With a warm summer climate, the area is a center of production of lemons, oranges, figs, chestnuts, grapes and beans.