Isesaki is located in the northwestern part of the Kantō Plain of southern Gunma Prefecture.

It is adjacent to Saitama Prefecture across the Tone River, which runs through the southern part of the city.

[7][8] Isesaki Town was created within Sai District, Gunma Prefecture on April 1, 1889 with the creation of the modern municipalities system after the Meiji Restoration.

Isesaki has a mayor-council form of government with a directly elected mayor and a unicameral city council of 29 members.

In terms of national politics, the city is part of the Gunma 2nd district of the lower house of the Diet of Japan.

It is also the location of J-List, a retailer of anime goods, visual novels and related products from Japan.

Isesaki has a Peruvian international school (ペルー学校), Colegio Hispano Americano de Gunma.