Ishaq Khan Khakwani (born 1 April 1949) is a senior Pakistani politician, engineer and a wealthy landlord.
He has also served on the Government Task Force on Agriculture, Reduction of WAPDA's electricity tariff and WTO.
He was amongst the more than 30 electables & heavyweights with Jehangir Tareen that joined Pakistan Tehreek e Insaf after its successful 30 October rally in Lahore.
Mr. Khakwani lost the election to PMLN candidate Syed Sajid Mehdi by a margin of 13,452 votes.
They have been settled in Multan for quite a while and the Khogyani Tribes' branch in Pakistan is known as the Khakwani family, and they are the major landowners in at least three of the four provinces and a minor presence in the fourth.