[1] She is best known for her performance as Saša in the TV drama series Jutro će promeniti sve,[2][3] which follows the lives of a group of young adults in contemporary Belgrade.
[5] Simijonović began her acting career with the play Pazi vamo performed in Boško Buha theatre in 2010, when she was still in high school.
[6] Her film career started with a lead role in the movie Klip, directed by Maja Miloš, when she was 16 years old.
[17] She played journalist Nataša in Porodica, a five-part drama series about the arrest of Slobodan Milošević, released in 2021.
[18][19] For her stage performance in Jami distrikt she received Dara Čalenic Foundation Award for the Best Young Actress on theatre festival Sterijino pozorje.