Isidro S. Lapeña (born January 2, 1951) is a Filipino retired police officer and former government official former served as director general of Technical Education and Skills Development Authority, Philippine Drug Enforcement Agency, and commissioner of Bureau of Customs.

[1] Lapeña's batchmates are former police general Thompson Lantion, and former Defense Secretary Delfin Lorenzana.

[4] Lapeña was appointed by then-President Duterte as Director of Philippine Drug Enforcement Agency from July 12, 2016, to August 30, 2017.

[2] But, in 2018, he was implicated in the Custom's drug smuggling scandal, and other officials for smuggling of the ₱11 billion worth of methamphetamine, locally known as shabu which was discovered inside the magnetic lifters in a warehouse in General Mariano Alvarez, Cavite.

[10] On October 25, 2018,[1] he was reassigned again, this time at the Technical Education and Skills Development Authority as its director general.