[2] Isipathana College is a national school for boys in Colombo, Western Province, Sri Lanka.

Presently it provides primary and secondary education on a campus of 4.5 ha (11 acres)[3] ranging from grades 1 to 13, with an enrollment of more than 7,500+ students.

The initial admissions were made by a board composed of principals of Royal College Colombo and Thurstan Colleges, and the headmaster of Royal Preparatory School; classes were organised in all three streams - Sinhala, Tamil and English, with a tutorial staff of seven teachers.

The first principal designed the college crest with the assistance of J. D. A. Perera and Stanley Abeysinghe of Heywood School of Art.

In 1956, Vihara Mandiraya and Chaitya were built to commemorate "Buddha Jayanthi year" at school premises.

Isipathana College was provided the Henry Pedris sports stadium on the 1st of July 2024 through a cabinet decision[5] for its use and management.

The names are derived from four poets - Thotagamuwe Sri Rahula Thera, Rabindranath Tagore, John Milton and Muhammad Iqbal.

The college commenced competitive rugby in 1960, led by Randy Keller, playing friendly games at under-17 levels.

Rugby at Isipathana began with Randy Keller, who was an ardent spectator at all the matches that his father played for Havelock SC.

Isipathana College has emerged as the most successful team in the history of this tournament, securing the championship title on eleven occasions.