Isla Apipé or Isla Apipé Grande is an Argentine island about 25 km long in the Paraná River[1] below the Argentine city of Posadas, Misiones, very marginally within the Argentina–Paraguay border, divided by river and a thin strip of variable marsh depending on the season.

Isla Apipé is part of Corrientes Province, separated from the rest of the province by a channel of the Paraná River and marsh up to the mean high water mark along a longer strip of the left bank belonging to Paraguay, a country which otherwise commences on the other side of the island.

In order the four islands measure about 276, 23.8, 11.8 and 3.7 km².

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