[1] Isle of Destiny stars William Gargan, Wallace Ford, June Lang and Gilbert Roland.The glamorous heiress and daredevil pilot Virginia Allerton (June Lang) is test-flying her seaplane "The Lady Bird" after some modifications made by her mechanic Max Raft (Ted Osborne), also on the aircraft.

Virginia's brother, Lt. George Allerton (Grant Richards), is stationed with the U.S. Marine Corps on the nearby island of Palo Pango when he hears his sister's distress calls.

Upon their arrival, Virginia and Max are welcomed by two U.S. Marines: "Stripes" Thornton (William Gargan) and "Milly" Barnes (Wallace Ford).

Virginia is unaware that Barton is planning to use her as cover for his shipment of guns about to take place on the steamer Albotros, commanded by Captain N. Lawson (Harry Woods).

It turns out Barton lives nearby and Virginia and Max are invited to be the guests of him and his Caribbean wife Inda (Katherine DeMille).

[3] Karen Morley was originally cast in the role of Virginia, but due to illness, was forced to leave the film and was replaced by June Lang.

[4] At the time of its production, Isle of Destiny had the biggest budget of any Fine Arts picture to date and marked the introduction of Cosmocolor to feature films.

[5] [N 1] Aviation film historian Christian Santoir compared the scenario depicted in Isle of Destiny to that of the real-life tragedy of Amelia Earhart being lost in the South Pacific.

"[7] Film historians Richard Jewell and Vernon Harbin in The RKO Story (1982) considered Isle of Destiny, "laughable exoticism" with "... wretched screenplay ... frenzied direction and inept performances by the lead actors..."[8]