Isola (French pronunciation: [izɔla]; Occitan: Lieusola) is a commune of the Alpes-Maritimes department in southeastern France.

The Alpine ski resort of Isola 2000 is located on the territory of the commune.

The average annual rainfall is 1,250.4 mm (49.23 in) with November as the wettest month.

The temperatures are highest on average in July, at around 13.0 °C (55.4 °F), and lowest in January, at around −4.0 °C (24.8 °F).

Since April 2010, Isola has been officially twinned with Castiglione di Garfagnana.