[1] Isoliquiritigenin occurs in some species of the genus Glycyrrhiza glabra (licorice).

[3] It also interferes with several cellular signaling pathways and has an anti-inflammatory effect, which may have applications in the treatment of inflammatory diseases.

[4] The enzyme 6'-deoxychalcone synthase uses malonyl-CoA, 4-coumaroyl-CoA, NADPH, and H+ to produce CoA, isoliquiritigenin, CO2, NADP+, and H2O.

Isoliquiritigenin has been found to be a potent (65 times higher affinity than diazepam) GABA-A benzodiapine receptor positive allosteric modulator.

[5] It can target miR-301b/LRIG1 signaling pathways, resulting in the inhibition of melanoma growth in vitro.