Isoma Karyon (Greek: Ίσωμα Καρυών) is a village in the municipality of Megalopoli, Arcadia, Greece.

It is situated in the eastern foothills of mount Lykaion, at 470 m elevation.

It is 2 km northwest of Kato Karyes, 6 km south of Karytaina and 8 km northwest of Megalopoli.