Isonokami no Yakatsugu (石上 宅嗣, 723 – July 23, 781) was a Japanese noble and scholar of the late Nara period.

Yakatsugu was rehabilitated, promoted to shō go-i no jō (正五位上), and made governor of Hitachi province.

Upon the death of Empress Shōtoku in 770, Yakatsugu aligned with Fujiwara no Nagate in supporting the future Emperor Kōnin as her successor.

The appreciative new emperor continued to value him, and Yakatsugu was promoted to chūnagon in 771 and dainagon in 780, making him the third highest ranking figure in the daijō-kan after udaijin Ōnakatomi no Kiyomaro and naidaijin Fujiwara no Uona.

During this period, he also held positions as head of the Dazaifu, shikibu-sho, Ministry of the Center, and Crown Prince's Quarters.