Despite the geographical distance that separates these two nations, their bilateral relationship has evolved over time, reflecting shared interests, diplomatic initiatives, and the pursuit of mutual cooperation.

The first Jew or Israeli to have set foot on Malta is traditionally considered to be Paul of Tarsus, an Israelite who was from the Roman province of Judea, in modern Israel, whose ship according to the legend foundered there in 62 CE.

The establishment of embassies in Tel Aviv and Valletta further solidified the foundation of their bilateral ties, providing tangible symbols of the relationship's significance.

The end of the Cold War and the Oslo Accords brought renewed attention to the Middle East peace process.

During this period, Malta demonstrated a commitment to contributing to regional stability and supporting efforts for a comprehensive peace agreement.

As a result, collaboration between the two nations expanded into areas such as technology, agriculture, and culture, reflecting the evolving nature of their diplomatic relationship.

The relationship extended beyond traditional areas of collaboration, encompassing counterterrorism efforts and joint responses to global humanitarian challenges.

[13][failed verification] Several common Maltese surnames are of Jewish origin, including Ellul, Cohen, Azzopardi, Meli, Deguara, Tabone, Lia, Cassar, and Said.

Academic institutions, cultural organizations, and individuals from both nations have engaged in cross-cultural interactions, fostering mutual understanding and empathy.