Fighting mainly in the U.S. and at junior featherweight, he beat 11 opponents, most notably Óscar Larios (20-0), before losing a split decision to Marcos Licona.

Vázquez scored 12 consecutive victories, and in 2002, he met Larios in a rematch for the interim WBC Super Bantamweight Title .

He fought Marquez for the third time on March 1, 2008, rising from a fourth round knockdown to prevail by split decision in another great fight.

[3][4] On December 18, 2008, Vázquez was stripped of his WBC Super Bantamweight Championship[5] after not defending the title for a certain period of time due to a detached retina he had suffered during his third fight with Márquez.

Japanese fighter Toshiaki Nishioka's WBC Interim title was promoted to actual championship status after his victory over Genaro Garcia.

The bout took place in the Featherweight division and was held at the Staples Center in Los Angeles, California, United States.

In October 2024 Vazquez was diagnosed with stage 4 sarcoma; he died from cancer in Los Angeles on December 3, 2024, at the age of 46.