Issa is the capital of the Daffiama Bussie Issa district in the Upper West Region of Ghana.

[1] Issa is at an elevation of 303 metres above sea level.

Its neighbours include Samambaw to the north, Kojoperi to the east, Tabeasi to the south and Wogu to the west.

[2] Issa is located on the southern border of the Gbele Resource Centre and bird sanctuary.

It is home to various endangered wildlife species as well as buffalo, hippopotamus, elephant, bushbuck and roan antelope.