Issac Luke was a part of the South Sydney squad that won the 2014 NRL Premiership, however despite being named as starting hooker, was ruled out for the final due to suspension.

[2] Luke's wife Mickayela is a cousin of fellow Kiwi rugby league international Sonny Bill Williams,[4] with whom he also played in the juniors at the Bulldogs.

[7] Prior to making his professional debut, Luke played Jersey Flegg Cup for Canterbury-Bankstown alongside fellow New Zealander and future Kiwis teammate Sonny Bill Williams.

Luke tasted finals football in his debut year, coming off the bench in South Sydney's 30 – 6 loss to the Manly-Warringah Sea Eagles.

Luke started the 2008 season well but a broken bone in his hand in the round 3 loss to the Penrith Panthers sidelined him for 4 weeks.

Luke was named at halfback for the round 8 clash against the North Queensland Cowboys to accommodate both himself and fellow hooker George Ndaira in the starting side.

In round 14 against the Gold Coast Luke scored his first career double and slotted the match winning penalty for a 24–23 victory.

[11] Luke was considered one of the 2008 Rugby League World Cup tournament's 'Players to Watch' by the NRL Live blog.

[12] He was then a crucial part of the Kiwi side that lifted the World Cup in 2008, beating Australia 34 – 20 before over 50,000 spectators at Brisbane's Lang Park.

[18] Following the grand final victory, Souths head coach Michael Maguire handed his premiership ring to Luke.