Issam Merdassi (Arabic: عصام المرداسي, born 16 March 1981) is a Tunisian footballer.

Merdassi played until 2006 for CS Sfaxien then went on loan to Saudi Al-Nassr before returning to CS Sfaxien for one season 2008–2009 and finally he was transferred to BSC Young Boys in summer 2009.

[1] He was a member of the Tunisian 2004 Olympic football team, who exited in the first round, finishing third in group C, behind group and gold medal winners Argentina and runners-up Australia.

[2] After managing Sfax Railways Sports, he was appointed manager of AS Rejiche in 2021.

[3] This biographical article related to Tunisian football is a stub.