Isse Mohamoud[1] or Eisse Mahmoud[2] (Somali: Ciise Maxamuud;[3][4] Arabic: عِيْسَىُ مَحَمُوْدً;) is a prominent sub-clan within the Majertein clan in Somalia,[5][6][7] comprising a significant population in four regional states primarily located in Puntland.

[8][9][10][11] The line of descent agreed upon by the ancestral family involves Eisse childbearing three sons: (Musse Eisse, Mohamed Eisse, Abokor Eisse)[12] [13][14] Isse Mahmoud exhibits two distinct traditions, known as (Issims), within their cultural framework.

However, despite the subdivision of the sub-clan into three subs, referred to as (Jifo), it is likely that they possess a comparatively lower number of traditional leaders, commonly referred to as (Sultan), in comparison to other tribes in Majertein.

[16][17] The structures of the clans and sub clans are not clearly agreed upon.

However, the following summarised clan tree presented below is taken from John Hunt's A general survey of the Somaliland Protectorate (1944-1950):[24]