Issele-uku is a town in Nigeria's Delta State and headquarters for the Local Government Area of Aniocha North.

[1] It is also the Episcopal See of the Bishop of the Roman Catholic Diocese of Issele-Uku.

It has its own post office and is served by the nearby new Asaba International Airport.

Issee-Uku is Anioma town in present-day Delta State.

[2] The Issele-uku Association of North America has written a brief history of this area including an explanation of the origin of the name of the city.