Issoudun (French pronunciation: [isudœ̃] ⓘ) is a commune in the Indre department, administrative region of Centre-Val de Loire, France.

[4][5] In 1499, Cesare Borgia, son of Pope Alexander VI, married Charlotte d'Albret, and as a dowry, was given, amongst other titles, the Lordship of Issoudun.

A very destructive one in 1651 was the result of an attack on the town in the war of The Fronde; Louis XIV rewarded its fidelity to him during that struggle by the grant of several privileges.

[3] In 1917, the U.S. Air Service established its largest European training centre, the 3rd Aviation Instruction Center, about 14 km (9 mi) northwest of the town.

Among the interesting buildings are the church of St Cyr, combining various architectural styles, with a fine porch and window, and the chapel of the Hôtel Dieu of the early 16th century.

Of the fortifications with which the town was formerly surrounded, a town-gate of the 16th century and the White Tower, a lofty cylindrical building of the reign of Philip II, survive.

Issoudun is home to the Musée de l'Hospice Saint Roch, that consistently hosts contemporary art exhibitions.