Issoudun-Létrieix (French pronunciation: [isudœ̃ letʁijɛ]; Occitan: Eissodun) is a commune in the Creuse department in the Nouvelle-Aquitaine region in central France.

A large area of forestry and farming, comprising the village and several hamlets situated some 7 miles (11 km) north of Aubusson, near the junction of the D54 and the D94 roads and also on the D990.

The commune is in the valley of the Creuse.

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