The journal is a forum for discussion of public policy related to science, technology, engineering, and medicine.

According to the journal's mission statement: "Unlike a popular magazine, in which journalists report on the work of experts, or a professional journal, in which experts communicate with colleagues, Issues is a place where researchers, government officials, business leaders, and others with a stake in public policy can share ideas with a broad audience.

When it comes to the relationship between society and advances in science and technology, the perspectives of the boardroom, the statehouse, the federal agency, and the community are as important as that of the laboratory.

"[1] The journal analyzes current topics in science, technology, and medicine, and seeks to provide recommendations by luminaries in government, industry, and academia to solve them.

The journal also produces a podcast, The Ongoing Transformation, which features discussions with policymakers, academics, and other expert contributors.