First they decide to do some good: Sweet Dee and Mac adopt a baby that was abandoned in a dumpster, Dennis volunteers with environmental rights activists, and everyone in the gang become vigilantes to solve Philadelphia's homeless problem.

The gang then hatches several schemes to become famous: Mac, Frank, and Charlie try to be viral video stars by covering the local news while Dennis and Dee seek fame as spoiled, drug-addled club hoppers.

Sweet Dee dates a local rapper mistakenly thought to be mentally disabled by Mac and Dennis, the two of whom start a band, but can't quite pinpoint their genre of music—especially when Charlie comes up with a raunchy, disjointed song about a mysterious creature who violates him in his sleep.

The entire gang struggles to compete with a local bar owned by a Korean man who looks like Kim Jong-il, and then decide to sell out by offering Paddy's Pub to a corporate chain.

Meanwhile, the gang sells some cocaine found in a pair of abandoned stereo speakers, forcing them to turn to crime and prostitution to earn the money back before some local Italian Mafia members "whack" (murder) them.