A young aviator, Carlos Martin (played by Raul Roulien), is dumped by his girlfriend (Gloria Stuart), and heads on a solo flight across the Pacific Ocean.

Shortly afterward, a pandemic of a new disease called "masculitis" kills every fertile male human on the planet.

The film was shot during April 1933, with location scenes photographed at the Grand Central Airport in Glendale, California.

[1] Other cast members include Edna May Oliver, Joan Marsh, Edward Van Sloan, and Peaches Jackson.

A sequence depicts look-a-likes of the two top scientists of the era, Albert Einstein and Auguste Piccard, trying to find a cure for masculitis.