Originally hosted by Vhong Navarro, Anne Curtis, Kim Atienza, Jugs Jugueta, Teddy Corpuz, and Vice Ganda, it premiered on October 24, 2009, on ABS-CBN's Unli PrimeTanghali line up replacing Pilipinas, Game Ka Na Ba?.

The original hosts include Vhong Navarro, Anne Curtis, Kim Atienza, Jugs Jugueta and Teddy Corpuz, with Vice Ganda as the resident hurado (unevictable judge).

[4][5] The drama series Mundo Man ay Magunaw and Kapamilya Blockbusters movie block took over the timeslot of Showtime from January 30 to February 3, 2012.

On March 10, 2020, It's Showtime temporarily stopped admitting a live audience in response to the government's declaration of a public health emergency due to the COVID-19 pandemic in the Philippines.

This action was taken in response to the National Telecommunications Commission's issuance of a cease and desist order to ABS-CBN's free-to-air stations, citing the expiration of the network's 25-year franchise.

[20] On June 13, 2020, the show resumed its broadcast with a shortened 150-minute timeslot on pay television network Kapamilya Channel, owned and operated by ABS-CBN Corporation.

[21][22] After serving as KapareWHO cast member and as resident dancer respectively, "Kuya Escort" Ion Perez and "Ate Girl" Jackie Gonzaga were promoted to co-hosts of the show.

[28] From March 18 to April 10, 2021, It's Showtime temporarily suspended their live productions due to the surge of COVID-19 cases in the Greater Manila Area caused by the SARS-CoV-2 Alpha variant.

[32] On October 2, 2021, Ogie Alcasid temporarily joined It's Showtime as guest co-host while Vice Ganda, Kim Chiu, Karylle and Ion Perez were on temporary leave.

[34][35] From January 6 to 15, 2022, It's Showtime temporarily suspended their live productions on a 10-day break due to the surge of COVID-19 cases in the country caused by the SARS-CoV-2 Omicron variant.

[38] A female dance segment Girl On Fire aired from October 2022 to February 18, 2023, with Jackie Gonzaga taking her first role as main host.

[48] On July 6, 2022, according to a report from MJ Marfori of TV5's flagship newscast Frontline Pilipinas, it was announced that It's Showtime would have a back-to-back collaboration with TV5's noontime show Tropang LOL, formerly known as Lunch Out Loud.

[56] A contract signing between the executives of ABS-CBN and GMA was held at Seda Vertis North on June 28, with former guest co-hosts Iya Villania and Robi Domingo hosting the said event.

From September to November 2023, the simulcast of It's Showtime on GTV was temporarily limited to 2 hours every Tuesday, Wednesday and Friday as it made way for the network's live broadcast of NCAA Season 99.

[58] It's Showtime temporarily ceased airing from October 13 to 27, 2023, to serve a 12-day suspension imposed by the Movie and Television Review and Classification Board (MTRCB).

GTV's simulcast silently ended on December 31, 2024, as It's Showtime continues to air on the main GMA Network channel and AMBS-owned All TV.

Later on, ABS-CBN and It's Showtime's social media accounts posted a video featuring a reveal that would take place on air via Facebook and YouTube.

Elimination Round: Selected hosts, including those from Showtime Online Ü, choose participants from a specific community for the game Tumpakners.

[85] It is also notable for Cianne Dominguez, who was a semifinalist and later became one of the show's main hosts; Jubilyn Sabino and Johaira Moris, who were both grand finalists, later became members of Showtime Baby Dolls.

[140][141] The program faced heavy competition in 2015 when the sixth anniversary special only scored a 10.2% national TV rating, four times behind Eat Bulaga's 40.1%.

[145] Tawag ng Tanghalan continued its winning streak during its second-season finale when it posted a national TV rating of 31% against Eat Bulaga's 9.5%.

[152] On July 18, 2024, It's Showtime once again achieved a historic victory since the ABS-CBN shutdown and return to the original frequencies through ALLTV last June 17, with a rating of 9.4% beating Eat Bulaga's 3.8%.

[153] A series of statements by guest judge Rosanna Roces against certain groups during an episode in January 2010 attracted controversy for perceived insensitivity towards teachers.

ABS-CBN relieved Roces of her jury duty as a form of self-regulation, but Movie and Television Review and Classification Board (MTRCB) placed the program under a 20-day preventive suspension on January 11, 2010.

The program responded to Gabriela's statement, saying that it is "hurtful and offensive to women like Angelica who has done nothing wrong but to share her story with the hope of getting another shot at love.

[166] On September 4, 2023, the MTRCB suspended the noontime show over an alleged obscene act by Vice Ganda and Ion Perez in a July 25 episode of the "Isip Bata" segment.

Juan Ponce Enrile, Chief Presidential Legal Counsel, criticized what he perceived as an immoral action on part of Vice and Ion.

[173] Teacher Tony Dizon issued an apology after mistakenly stating that Gloria Macapagal Arroyo was the first female president of the Philippines instead of Corazon Aquino on the show's trivia segment Throwbox on September 19, 2024.

Acknowledging the backlash and accusations of boastfulness after sharing his academic achievements, Dizon expressed surprise at the mistake, noting the pressure of performing live.

Isip Bata: The Album is a compilation album of eleven music tracks featuring the members of the kiddie group "Batang Cute-Po" (then called Showtime Kids) of the show's children's segment "Isip Bata", consisting of Argus Aspiras, Imogen Cantong, Princess Kathryn "Kulot" Caponpon, Jaze Capili, and Lucas Landicho was released on November 3, 2023.