[8] They were accompanied by two servants and their tutor and interpreter Diego de Mesquita,[9] as well as by Valignano himself, who escorted them to Goa in India before taking on a new post.

[8] During their stay in Europe the group met King Philip II of Spain,[16] the Grand Duke of Tuscany Francesco I de 'Medici,[17] Pope Gregory XIII and his successor, Sixtus V.[18] Joining the order of Jesuit priests in 1608[19] he engaged in missionary work in northwest Japan but soon was expelled from the local Kokura domain and then moved to the Nakatsu Domain.

[20] A portrait depicting Itō Mancio was discovered in 2008 and entrusted to the care of experts who identified its authenticity and attributed its creation to Domenico Tintoretto.

In reality, the portrait was made by his son Domenico, remaining in stock in the Tintorette workshop until the Spanish collector Gaspar Méndez de Haro, Marquis del Carpio, bought the entire collection of the two artists.

Due to his debts, however, he was forced to sell all his assets and the work ended up in the hands of the Florentine banker Giovanni Francesco del Rosso who in turn ceded it to the Rinuccini family of Florence.

[21] The painting was restored in 2009 and exhibited in Tokyo, Nagasaki and Miyazaki (Mancio's place of origin) on the occasion of the celebrations of the 150th anniversary of the beginning of diplomatic relations between Italy and Japan in 2016.